Development of a New Combination Compound (Cyclopamine) Isolated from Veratrum californicum and 5-FU Acting as Anti-invasive and Initiator of Intrinsic Apoptosis Mechanism against Aggressive Type Colorectal Cancer Cells

Characteristics of programmed cell death are generally regarded as defined by outgrowth or cellular aging and distinct morphological characteristics featuring nuclear condensation formation apoptotic bodies. Apoptosis is considered to have a function at level essential long-lived differentiation undergoing senescence apoptosis. Inappropriate apoptosis factor that results in serious conditions, causing multiple disease progression well cancer. The ability modulate the life cancer recognized for its immense therapeutic potential. Therefore, research findings focused on elucidation newly synthesized drug derived from natural plant stop cycle mechanism signaling pathways control arrest necessary. field moving forward rapid rate. goal this paper investigate active constituent, which simply identified “a near future co-chemotherapy”, explore activate pathway. Our demonstrated cyclopamine provides an excellent anti-tumor activity changing morphology cancerous cells early late phases apoptosis, indicating has potential chemosensitize SW-620 5-FU based chemotherapy, may be useful treatment colorectal fight overcome resistance advanced